Spontaneous mouse lymphoma in patient-derived tumor xenografts: The importance of systematic analysis of xenografted human tumor tissues in preclinical efficacy trials

• DOI: 10.1016/j.tranon.2021.101133
• Publication Date: 2021-05-26T11:05:49Z
• Authors: Sophie Chateau-Jo...; Miriam Hopfe; Sophie Richon; Didier Decaudin; Sergio Roman-Roman; Edouard Reyes-Gomez; Ivan Bieche; Fariba Nemati; Virginie Dangles-...
• Keywords: Preclinical testing; Preclinical research

Patient-derived tumor xenograft (PDX) is now largely recognized as a key preclinical model for cancer research, mimicking patient phenotype and genotype. Immunodeficient mice, well-known to develop spontaneous lymphoma, are required PDX growth. As all animal models used further clinical translation, robust experimental design strongly lead conclusive results. Here we briefly report unintentional co-engraftment of mouse lymphoma during expansion well-established PDXs illustrate the importance systematic check identity avoid misinterpretation. Besides, this quality control based on complementary approaches deserves more detailed description in materials methods section ensure validity reproducibility.