Does Preoperative Fine Needle Aspiration-Biopsy Produce Tumor Recurrence in Patients Following Liver Transplantation for Hepatocellular Carcinoma?
Adult
Male
Carcinoma, Hepatocellular
Time Factors
Adolescent
Patient Selection
Biopsy, Fine-Needle
Liver Neoplasms
Middle Aged
Survival Analysis
Liver Transplantation
3. Good health
03 medical and health sciences
Treatment Outcome
0302 clinical medicine
Recurrence
Preoperative Care
Humans
Female
Neoplasm Invasiveness
Aged
Follow-Up Studies
Retrospective Studies
DOI:
10.1016/j.transproceed.2005.09.169
Publication Date:
2005-12-29T07:13:10Z
AUTHORS (11)
ABSTRACT
Liver transplantation (OLT) has been advocated for patients with carcinoma hepatocellular (HCC). A preoperative biopsy (fine needle aspiration biopsy) [FNA] facilitates preoperative diagnosis of adverse pathological factors: vascular invasion or histologicalic differentiation. But a biopsy may cause abdominal dissemination and be related to a higher incidence of recurrence.From April 1986 to December 2003, we performed 95 OLT for HCC. We divided them in two groups: group A without FNA-biopsy (67.9%) and group B with FNA-biopsy (32.1%).We obtained the diagnosis of HCC in only 15 patients (57.6%). In two patients an OLT was avoided due to the presence of abdominal dissemination at the time of transplant. Recurrence incidence was higher among group B patients (5.9% vs 31.8%; P = .003) due to extrahepatic recurrence (2% vs 27.3%; P = .003). No differences were observed in morbidity or mortality. The two groups were homogeneous in epidemiological and pathological variables except: sex distribution, Child status, AFP level, tumor size, and pTNM stage. If we compare recurrence rates in the two groups attending to these nonhomogeneous variables, it was significantly higher among patients with tumors larger than 3 cm, pTNM I-III stage, Child B-C, AFP >200 ng/mL, and males or females.Preoperative liver biopsy is associated with a larger incidence of tumor recurrence, so we believe that it is not necessary prior to an OLT for HCC.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (22)
CITATIONS (49)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....