High Incidence of Malignancy in Polyomavirus-Associated Nephropathy in Renal Transplant Recipients
Polyomavirus Infections
JC Virus
Kidney Transplantation
Medical Records
3. Good health
Tumor Virus Infections
03 medical and health sciences
0302 clinical medicine
BK Virus
Neoplasms
Prevalence
Animals
Humans
Kidney Diseases
Retrospective Studies
DOI:
10.1016/j.transproceed.2010.02.068
Publication Date:
2010-04-28T13:03:01Z
AUTHORS (10)
ABSTRACT
Human polyomaviruses (PV), including JC and BK virus, have been reported to cause polyomavirus-associated nephropathy (PVAN), in renal transplant patients. PV infection has been demonstrated to be associated with malignancies in animals; however, the association between malignancy and viral infections in humans is not clear. We retrospectively reviewed our 864 (M:F=502:362) kidney transplant patients over the past 25 years. We identified PVAN in 6 patients (0.69%), including BK nephropathy (n=5) and JC nephropathy (n=1). Three patients (50%) improved after reducing the immunosuppression, but 3 (50%) progressed to graft loss despite this reduction. Malignancy occurred in 5 out of the 6 patients (83%; P<.0001 compared with patients without PVAN), including transitional cell carcinoma (n=2), renal cell carcinoma (n=1), squamous cell carcinoma of skin (n=1) and Kaposi sarcoma (n=1). We concluded that kidney transplant patients with PVAN are at a significantly greater risk to develop malignancy. Whether this is due to a direct effect of PV infection or the result of overimmunosuppression remains to be determined in a future study.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (8)
CITATIONS (20)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....