Severe Aplastic Anemia and a Healthy Pregnancy Immediately Following Syngeneic Transplantation: An Extremely Rare Case Report

• DOI: 10.1016/j.transproceed.2023.02.020
• Publication Date: 2023-03-15T14:18:19Z
• Authors: Ibrahim Ethem Pınar; Fahir Özkalemkaş; Tuba Ersal; Vildan Gürsoy; Esra Gülderen; Vildan Özkocaman
• Keywords: Aplastic anemia; Savior sibling

Aplastic anemia is potentially fatal, particularly if the disease does not respond to immunotherapy and progresses to severe pancytopenia. Allogeneic hematopoietic stem cell transplant from an HLA-matched sibling donor, the first-line treatment in patients younger than 40 years, is used as a curative treatment option in severe aplastic anemia. The availability of an identical twin donor is infrequent, and there is limited experience in this context. Additionally, the choices for a conditioning regimen for a syngeneic transplant to prevent engraftment failure and the necessity of graft-vs-host disease prophylaxis are controversial. Although long-term survival gradually increases after an allogeneic hematopoietic stem cell transplant, hypogonadism and infertility are the main problems that significantly affect patients' quality of life. We present a patient diagnosed with severe aplastic anemia who has had a healthy pregnancy immediately after a syngeneic transplant.