Magnetic Resonance Diffusion Tensor Imaging Characterize the Hepatic Ischemia-Reperfusion Injury in an Animal Study

• DOI: 10.1016/j.transproceed.2023.04.045
• Publication Date: 2023-06-30T04:52:56Z
• Authors: Minglu Liu; Cheng Zhang; Sandi Shen; Jiakang Shao; Ying Wang; Shunchang Jiao; Chengwei Guo
• Keywords: Histopathology

Hepatic ischemia-reperfusion (I/R) injury is the main cause of morbidity and mortality after hepatectomy; thus, new methods for reducing I/R are required. The aim this study to evaluate changes in average apparent diffusion coefficient (ADCavg) fractional anisotropy (FA) rabbits with partial hepatic magnetic resonance tensor imaging (DTI).The left lobe rabbit liver underwent 60 minutes ischemia followed by 0.5, 2, 6, 12, 24, 48 hours reperfusion. T2-weighted images (T2WI), T1-weighted (T1WI), DTI, contrast-enhanced T1WI were performed; 6 b values used DTI on directions. serum levels transaminases histopathology findings examined.In early stage (0.5 hour), ADCavg decreased significantly increased sharply 2 hours, then from reperfusion, except a transient decrease (24 hours). Meanwhile, FA showed almost opposite trend, drastically increasing during first 0.5 hour slightly decreasing until an obvious 2-hours group. markers pathologic scores group reperfusion correlated tissue I/R.Diffusion feasible I/R-induced damage can discriminate isotropic properties objective FA. Diffusion be promising novel approach use clinical management surgery.