A Pilot Study of Nephrogenic Probiotics to Further Improve an Already Stabilized Graft Function After Kidney Transplantation

• DOI: 10.1016/j.transproceed.2023.08.011
• Publication Date: 2023-10-07T07:07:20Z
• Authors: Wai-Nga Chan; Dong-Ru Ho; Yun-Ching Huang; Jian-Hui Lin; Yu-Liang Liu; Ming-ju Chen; Chih-Shou Chen
• Keywords: Graft Rejection; Mice; Creatinine; Animals; Humans; Pilot Projects; Kidney Transplantation; Immunosuppressive Agents; Tacrolimus; 3. Good health; Retrospective Studies; Glomerular Filtration Rate

The majority of kidney recipients are a subset chronic disease. Our previous study demonstrated that the combination Lactobacillus plantarum and paracasei (Lm) had highest clearance ability uremic toxins improved function in mouse model. This aimed to evaluate Lm improving graft function, effects on immunosuppressants, safety transplant recipients.We retrospectively reviewed 24 patients. Twelve them take regularly; we compared creatinine measurements estimated glomerular filtration rate 3 months before after using 2-tailed Wilcoxon matched-pairs signed-rank test while also evaluating drug level immunosuppressants infection events. Other 12 patients who do not have for evaluation laboratory calibration proportion Fisher's exact test.The decreased by 0.06 mg/dL (P = .02), increased 3.1 mL/min/1.73 m2 .03) supplementation. pilot revealed association higher incidence (odds ratio 13.3, 95% CI 1.64-77.2, P .01) decreasing Lm. Furthermore, results showed trend trough levels tacrolimus sirolimus, which might provide potential strategy reducing dosages immunosuppressants.Our findings an between Lm, may acquired immunosuppressants.