Pregnancy in Liver and Kidney Female Recipient: A Case Report

• DOI: 10.1016/j.transproceed.2024.03.033
• Publication Date: 2024-05-10T07:02:29Z
• Authors: Zoulikha Jabiry-Z...; Daria Ada Stelmach; Kamil Jasak; Weronika Knap-Wie...; Agnieszka Szumska; Piotr Kalicinski; Joanna Sanko-Resmer; Monika Szpotanska...
• Keywords: Adult; Pregnancy Complications; Hepatolenticular Degeneration; Pregnancy; Humans; Kidney Failure, Chronic; Female; Acute Kidney Injury; Kidney Transplantation; Immunosuppressive Agents; Liver Transplantation

Deterioration of kidney function after orthotopic liver transplantation is a common complication that may occur after perioperative acute kidney injury (AKI) and preexisting or developing chronic kidney disease (CKD). AKI is described in the early postoperative period in more than half of recipients, whereas the main cause of CKD is pharmacotherapy. When end-stage renal failure occurs, patients may be qualified for additional transplantations. We present a rare case of a 27-year-old woman who, as a teenager, underwent 2 liver transplantations due to Wilson's disease. Surgeries were complicated by systemic infection and multiple organ failure. The kidneys did not regain their function, and therefore, after 6 months of dialysis, the organ was transplanted. Three organ transplantations were performed. Due to the patient's willingness and good graft functions, the patient started trying to conceive. Three months before successful conception, immunosuppressive therapy was changed to tacrolimus and azathioprine. Pregnancy was complicated by pregnancy-induced hypertension, and its course was closely monitored. Organ functions and immunosuppressive therapy were regularly assessed. Due to the pre-eclampsia developed in the 35th week of gestation, a Cesarean delivery was performed, and she gave birth to a daughter weighing 2350 g (Apgar 7-7-8). The patient decided to breastfeed. There were no obstetric complications or graft function deterioration in the early postpartum period. Mother and daughter left home after 7 days of hospitalization. The presented clinical situation proves that multiorgan transplantation recipients can have a successful pregnancy without impairing graft functions. Therefore, the pregnancy requires adequate preparation and increased care.