Displacement Patterns in Magnetomotive Ultrasound Explored by Finite Element Analysis

• DOI: 10.1016/j.ultrasmedbio.2021.10.011
• Publication Date: 2021-11-18T14:03:59Z
• Authors: Sandra Sjöstrand; Maria Evertsson; Esayas Atile; Roger Andersson; Ingrid Svensson; Magnus Cinthio; Tomas Jansson
• Keywords: Diamagnetism

Magnetomotive ultrasound is an emerging technique that enables detection of magnetic nanoparticles. This has implications for molecular imaging, and potentially addresses clinical needs regarding determination metastatic infiltration the lymphatic system. Contrast achieved by a time-varying field sets nanoparticle-laden regions in motion. motion governed vector-valued mechanical forces. Understanding how these forces contribute to observed displacement patterns important interpretation magnetomotive images. Previous studies have captured adjacent was attributed diamagnetism. While diamagnetism could give rise force, it cannot fully account displacements ultrasound. To isolate explanatory variables displacements, finite element model set up. Using this model, we explore potential causes unexplained comparing numerical models with earlier experimental findings. The simulations reveal outside particle-laden be coupling principle mass conservation. These factors produced counterbalanced excitation, whose extent distribution affected boundary conditions as well compressibility stiffness surroundings. Our findings emphasize importance accounting force imaging. In axisymmetric geometry, can represented simple scalar expression, oversimplification rapidly becomes inaccurate distance from symmetry axis. Additionally, results underestimation vertical component up 30%. We therefore recommend using full capture interaction. study enhances our understanding govern nanoparticle tissue, contributing accurate analysis