Ultrasound promoted synthesis of 5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles and β-enamino trihalomethyl ketones in water

• DOI: 10.1016/j.ultsonch.2005.04.009
• Publication Date: 2005-07-13T19:42:51Z
• Authors: Marcos A.P. Martins; Claudio M.P. Pereira; Wilson Cunico; Sidnei Moura; Fernanda A. Rosa; Rodrigo L. Peres; Pablo Machado; Nilo Zanatta; Helio G. Bonacorso
• Keywords: 01 natural sciences; 0104 chemical sciences

A convenient method for the preparation of 5-hydroxy-5-trihalo-4,5-dihydroisoxazoles and beta-enamino trihalomethyl ketones, from the reaction of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones with hydroxylamine and anilines, respectively, using water as solvent and under ultrasound irradiation is reported.