Sonochemistry: A good, fast and clean method to promote the synthesis of 5-arylidene-2,4-thiazolidinediones

• DOI: 10.1016/j.ultsonch.2014.04.013
• Publication Date: 2014-04-30T19:01:51Z
• Authors: Bruna B. Drawanz; Camila S. Ribeiro; Hellen G. Masteloto; Patrícia D. Neuen...; Claudio M.P. Pereira; Geonir M. Siqueira; Wilson Cunico
• Keywords: Sonochemistry; Thiazolidinedione; Aldol condensation

The efficient synthesis of sixteen 5-arylidene-2,4-thiazolidinediones by aldol condensation reaction of 2,4-thiazolidinedione, mono- and di-substituted arenealdehydes and KOH using ultrasound irradiation is reported. The desired compounds were obtained in a few min (10-30 min) with moderate to good yields (25-81%).