Familial Associated Idiopathic Urethral Stricture Disease: An Assessment Using Pedigree Data From the Utah Population Database

• DOI: 10.1016/j.urology.2025.03.056
• Publication Date: 2025-04-08T21:03:42Z
• Authors: Kevin J. Hebert; Joshua J. Horns; Niraj Paudel; Bradley A. Erickson; Matthew Grimes; Michael B. Christ...; Joemy Ramsay; Benjamin J. McCor...; James Hotaling; Jeremy B. Myers

To elucidate the role of familial transmissibility idiopathic urethral stricture disease (USD) using Utah Population Database. identify patients with USD, we excluded: post-infective, post-traumatic, post-operative, and hypospadias related USD. Each case was matched to a control (1:1). All male relatives (1st-3rd degree) cases controls were identified. A Cox-proportional hazards model performed assess effect being an USD relative versus relative. Models including all separated by degree relationship index performed. We identified 7939 US which 1:1 7015 controls. 60,694 60,098 identified, for total cohort 120,792 patients. Median follow-up entire 25.7 years (IQR;13.4, 27.4). 1st, 2nd, 3rd contributed 14.3%, 28.1%, 57.7% cohort, respectively. 328 (0.54%) within compared 122 (0.2%) population, (p<0.001). Hazard ratios estimating included: any relation (HR 2.6; p<0.001), first-degree 14.0; second-degree 1.7; p=0.02), third-degree 1.3; p=0.12). When relatives, those more likely have family members also affected suggesting transmission pattern