Immunological parameters related to the adjuvant effect of the ordered mesoporous silica SBA-15

• DOI: 10.1016/j.vaccine.2010.09.087
• Publication Date: 2010-10-11T14:47:22Z
• Authors: Luciana V. Carvalho; Rita de C. Ruiz; Karina Scaramuzzi; Eliana B. Marengo; Jivaldo R. Matos; Denise V. Tambourgi; Marcia C.A. Fantini; Osvaldo A. Sant’Anna
• Keywords: Splenocyte

In 2006, the first report of a nanostructured material as adjuvant was described establishing effectiveness ordered mesoporous SBA-15 silica an immune adjuvant. The present study evaluated capacity to modulate responsiveness High and Low responder mice immunized with BSA encapsulated/adsorbed in by intramuscular or oral route effect compared induced aluminum hydroxide salts emulsified Incomplete Freund These results demonstrate ability non-toxic nanoparticles increase immunogenicity repair constitutively low individuals inducing both IgG2a IgG1 isotypes, independently cell committed conditioning phenotype. This new may reveal novel therapeutic targets for modulation vaccine design.