Immunogenicity of conjugate Meningococcus C vaccine in pediatric solid organ transplant recipients

• DOI: 10.1016/j.vaccine.2011.06.033
• Publication Date: 2011-06-30T01:48:35Z
• Authors: Manuela Zlamy; Johannes Elias; Ulrich Vogel; Matthias Frosch; Verena Jeller; Gerard Cortina; Therese Jungraith...; Martina Prelog
• Keywords: Male; Vaccines, Conjugate; Adolescent; Vaccination; Immunization, Secondary; Meningococcal Vaccines; Neisseria meningitidis, Serogroup C; Organ Transplantation; Meningitis, Meningococcal; Serum Bactericidal Antibody Assay; Antibodies, Bacterial; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Child

The present study was aimed to evaluate the immunogenicity of a single dose of conjugate Meningococcus C (Men C) vaccine by analyzing the serum bactericidal antibody (SBA) titers in 10 pediatric solid organ transplant (SOT) patients. Four patients showed a delayed immune response after 1 month, but all patients demonstrated an increase of SBA titers after vaccination. A significant decrease of SBA titers was seen after 6 months. However, all patients maintained protective SBA titers (≥1:8) despite rapidly waning titers. For patients with significantly decreasing titers, a booster dose may be discussed with close monitoring of SBA titers over time.