Immunogenicity of a three dose and five dose oral human rotavirus vaccine (RIX4414) schedule in south Indian infants

• DOI: 10.1016/j.vaccine.2014.03.002
• Publication Date: 2014-08-02T19:36:55Z
• Authors: Rajeev Zachariah ...; Anu Paul; Divya Manoharan; Sudhir Babji; Rajiv Sarkar; Leni G. Mathew; Gagandeep Kang
• Keywords: Seroconversion; Rotavirus vaccine; Vaccination schedule

This study was undertaken to compare the immunogenicity of a three dose and five schedule an oral live-attenuated human rotavirus vaccine, Rotarix® in south Indian infants. Healthy infants (N = 90), six seven weeks age were enrolled receive doses (n 45) or Rotarix vaccine along with other scheduled vaccines, each separated by four week interval. Blood samples taken before vaccination one month post-dose group group; all tested for anti-rotavirus IgA antibody sandwich enzyme immunoassay. At baseline, >50% had >20 units IgA. The seroconversion rates after low not significantly different two groups. However, among responders, children seropositive at baseline showed much greater absolute increase levels than seronegative baseline. increasing number did proportion seroconverting vaccination.