Invasive disease potential of pneumococci before and after the 13-valent pneumococcal conjugate vaccine implementation in children

• DOI: 10.1016/j.vaccine.2015.10.015
• Publication Date: 2015-10-25T02:33:50Z
• Authors: Emmanuelle Varon; Robert Cohen; Stéphane Béchet; Catherine Doit; Corinne Levy
• Keywords: Pneumococcal Conjugate Vaccine; Pneumococcal pneumonia; Pneumococcal infections

Changes in serotype distribution have been induced after pneumococcal conjugate vaccines (PCV) implementation, and non-vaccine serotypes are now circulating. Among these latter serotypes, we aimed to distinguish those with high invasive disease potential before (2008-2009) PCV13 implementation (2012-2013).Invasive (IPD) isolated from children 6 24 months were compared nasopharyngeal-colonizing healthy children. To assess the of a given serotype, odds ratios (ORs) calculated. For each OR >1 indicated increased probability association IPD <1 decreased probability.In 2008/2009 2012/2013, 355 pneumococci 1212 569 IPD, including 166 meningitis, 114 pneumonia, 289 other IPDs. In period 1, 7F, 3, 24F, 19A showed highly significant whereas 2, only 24F was associated (6.6 [95% CI 2.6; 16.2]). Of note, for 12F, could not be calculated because no carrier recorded, however, if there had single 12F carrier, would among highest, 15.7 3.4; 73.0]). Only two appeared negatively 11A 23B 2 as nine 1. second period, penicillin non-susceptible isolates mostly represented by 19A, 15A, 19F, 35B both carriers IPD. one strain resistant MIC=4 μg/ml (serotype 19A) during first period.In <2 years old, previous number having potential.