Building capacity for active surveillance of vaccine adverse events in the Americas: A hospital-based multi-country network
Purpura, Thrombocytopenic, Idiopathic
Capacity Building
Drug-Related Side Effects and Adverse Reactions
International Cooperation
EMC NIHES-03-77-02
World Health Organization
Proof of Concept Study
Hospitals
3. Good health
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
Epidemiological Monitoring
Humans
Meningitis, Aseptic
Americas
Measles-Mumps-Rubella Vaccine
Retrospective Studies
DOI:
10.1016/j.vaccine.2017.04.069
Publication Date:
2017-08-10T10:15:33Z
AUTHORS (38)
ABSTRACT
New vaccines designed to prevent diseases endemic in low and middle-income countries are being introduced without prior utilization in countries with robust vaccine pharmacovigilance systems. Our aim was to build capacity for active surveillance of vaccine adverse events in the Americas. We describe the implementation of a proof-of-concept study for the feasibility of an international collaborative hospital-based active surveillance system for vaccine safety. The study was developed and implemented in 15 sentinel sites located in seven countries of the region of the Americas, under the umbrella of the World Health Organization (WHO) Global Vaccine Safety Initiative. The study evaluated the associations between measles-mumps-rubella vaccines and two well-recognized adverse events: Immune thrombocytopenic purpura (ITP) and aseptic meningitis. The regional network contributed 63 confirmed ITP and 16 confirmed aseptic meningitis eligible cases to the global study, representing, respectively, 33% and 19% of the total cases. To ensure long-term sustainability and usefulness to investigate adverse events following new vaccine introductions in low and middle-income countries, the network needs to be strengthened with additional sites and integrated into national health systems.
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