Modeling COVID-19 vaccine booster-elicited antibody response and impact of infection history

• DOI: 10.1016/j.vaccine.2023.11.040
• Publication Date: 2023-11-25T20:25:33Z
• Authors: Takara Nishiyama; Yuichiro Miyamatsu; Hyeongki Park; Naotoshi Nakamura; Risa Yokokawa Shi...; Shingo Iwami; Yoji Nagasaki
• Keywords: Booster (rocketry); Booster dose; Pandemic

The 3-dose COVID-19 vaccine (booster vaccination) has been offered worldwide. As booster vaccinations continue, it is important to understand the antibody dynamics elicited by vaccination in order evaluate and develop needs strategies. Here, we investigated longitudinal data monitoring IgG antibodies against receptor binding domain (RBD) health care workers. We extended our previously developed mathematical model vaccines successfully fitted titers over time absence presence of past SARS-CoV-2 infection. Quantitative analysis using indicated that anti-RBD increase a comparable extent after vaccination, regardless or infection, but infection history extends duration response 1.28 times. Such modeling approach can be used inform future strategies on basis an individual's immune history. Our simple quantitative any kind therefore form for policy decisions regarding distribution strengthen immunity pandemics.