Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the NF-κB signaling pathway

• DOI: 10.1016/j.virs.2022.11.010
• Publication Date: 2022-11-28T05:54:39Z
• Authors: Chaoxiang Lv; Yuanguo Li; Tiecheng Wang; Qiqi Zhang; Jing Qi; Mingwei Sima; Entao Li; Tian Qin; Zhuangzhuang Shi; Fangxu Li; Xuefeng Wang; Weiyang Sun; Na Feng; Songtao Yang; Xianzhu Xia; Ningyi Jin; Yifa Zhou; Yuwei Gao
• Keywords: Mice, Inbred BALB C; 0303 health sciences; Influenza A Virus, H5N1 Subtype; Taurine; NF-kappa B; Virus Replication; Antiviral Agents; 3. Good health; Mice; 03 medical and health sciences; Orthomyxoviridae Infections; Influenza A virus; Influenza in Birds; Animals; Research Article; Signal Transduction

Taurolidine (TRD), a derivative of taurine, has anti-bacterial and anti-tumor effects by chemically reacting with cell-walls, endotoxins exotoxins to inhibit the adhesion microorganisms. However, its application in antiviral therapy is seldom reported. Here, we reported that TRD significantly inhibited replication influenza virus H5N1 MDCK cells half-maximal inhibitory concentration (EC50) 34.45 ​μg/mL. Furthermore, drug amplification cytokine storm effect improved survival rate mice lethal challenged (protection was 86%). Moreover, attenuated virus-induced lung damage reduced titers lungs. Administration number neutrophils increased lymphocytes blood virus-infected mice. Importantly, regulated NF-κB signaling pathway inhibiting separation IκBa, thereby reducing expression inflammatory factors. In conclusion, our findings suggested could act as potential anti-influenza candidate further clinical studies.