Identification and characterization of P2-like bacteriophages of Yersinia pestis

• DOI: 10.1016/j.virusres.2022.198934
• Publication Date: 2022-09-20T01:42:29Z
• Authors: Zhizhen Qi; Biao Meng; Xiao Wei; Xiang Li; Hong Peng; Yan Li; Qunling Feng; Yanan Huang; Qi Zhang; Xiaoqing Xu; Haihong Zhao; Xiaoyan Yang; Changjun Wang; Xiangna Zhao
• Keywords: Yersinia pestis; Identification; Yersinia

Yersinia pestis is the cause of plague, historically known as "Black Death". Marmota himalayana in Qinghai-Tibet Plateau (QTP) natural plague focus primary host China. Although several phages originating from Y. have been characterized. This first report isolation P2-like M. himalayana. In this study, and characterization three were reported, which named vB_YpM_22, vB_YpM_46 vB_YpM_50. Comparative genome analysis revealed that vB_YpM_50 are members nonlambdoid P2 family, highly similar collinear with enterobacteriophage P2, diagnostic phage L-413C fiAA91-ss. The role LPS core structure phages' receptor was pinpointed. findings study contribute an advance our current knowledge will also play a key understanding evolution phages.