Transcriptomics-based investigation of resistance differences to swine fever between large white pigs and min pigs

• DOI: 10.1016/j.virusres.2025.199536
• Publication Date: 2025-02-01T06:31:30Z
• Authors: Jia Li; Deming Ren; Xiangxu Meng; Yiyun He; Lixian Wang; Xihui Sheng; Ligang Wang
• Keywords: Large white; White (mutation)

The genetic foundations underlying the observed disease resistance in certain indigenous pig breeds, notably Min pigs of China, present a compelling underexplored subject study. Exploring mechanisms these breeds could lay groundwork for improvements immunity, potentially augmenting overall productivity. In this study, whole blood samples were collected from pre- and post- swine fever vaccinated Large White transcriptome sequencing. mRNA lncRNA both analyzed, intra-group inter-group comparisons also conducted. results indicated that greater number immune-related pathways such as JAK-STAT PI3K-AKT signaling enriched pigs. Furthermore, genes involved inflammation antiviral responses, including IL16, IL27, USP18, DHX58, upregulated post-vaccination compared to This heightened immune responsiveness contribute differences between