Hypersensitivity reactions amongst Hungarian Patients with Hereditary Angioedema due to C1-Inhibitor Deficiency

• DOI: 10.1016/j.waojou.2023.100833
• Publication Date: 2023-10-23T15:55:37Z
• Authors: Hanga Réka Horváth; Dávid Szilágyi; Noémi Andrási; Zsuzsanna Balla; Beáta Visy; Henriette Farkas
• Keywords: Hereditary Angioedema; C1-inhibitor

BackgroundIn hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE), bradykinin-mediated submucosal and/or subcutaneous dominates the clinical picture. The of can lead over-activation complement system. Complement plays an important role in all types hypersensitivity reactions. On other hand, during degranulation mast cells, heparin is also released amongst substances. Heparin activate plasma kinin-kallikrein system, leading bradykinin generation. These observations suggest a possible connection between C1-INH-HAE and cell-mediated reactions.ObjectiveTo assess occurrence reactions Hungarian population.MethodsPatients filled out questionnaire 112 questions, either online or on paper. questions were about symptoms, relation these 2, general health, demographic data. study protocol was approved by institutional review board Semmelweis University, Budapest, informed consent obtained from participants.ResultsOne hundred six patients (64 female, 42 male, median age 46 years) responded, with 63.2% having hypersensitivity. Hypersensitivity provoked pollen 25.5% patients, contact sensitivity 22.6%, food 21.7%, insect sting 19.8%, pet 15.1%, drug 14.2%, dust mite 5.7%, mold 1.9%. In 11 symptoms appeared after diagnosis C1-INH-HAE. Six hypersensitive experienced improvement their symptoms; remained same, but none worsening 7.8% attack worsened while 15.7% provoking factor.ConclusionWhile our have reported Eurostat's latest data puts prevalence self-reported allergies Hungary at 19.3%. Since experience most report as allergies, this may support 2 diseases, further molecular studies are needed.