Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi

• DOI: 10.1016/j.xcrm.2022.100662
• Publication Date: 2022-06-21T14:54:21Z
• Authors: Rhea J. Longley; Matthew J. Grigg; Kael Schoffer; Thomas Obadia; Stephanie Hyslop; Kim A. Piera; Narimane Nekkab; Ramin Mazhari; Eizo Takashima; Takafumi Tsuboi; Matthias Harbers; Kevin Tetteh; Chris Drakeley; Chetan E. Chitnis; Julie Healer; Wai-Hong Tham; Jetsumon Sattabon...; Michael T. White; Daniel J. Cooper; Giri S. Rajahram; Bridget E. Barber; Timothy William; Nicholas M. Anstey; Ivo Mueller
• Keywords: Plasmodium knowlesi; Cross-reactivity

Serological markers are a promising tool for surveillance and targeted interventions Plasmodium vivax malaria. P. is closely related to the zoonotic parasite knowlesi, which also infects humans. knowlesi co-endemic across much of South East Asia, making it important design serological that minimize cross-reactivity in this region. To determine degree IgG against panel markers, we assayed samples from human patients with antibody reactivity high proteins sequence identity their ortholog. peaks at 7 days post-P. infection short-lived, minimal responses 1 year post-infection. We designed eight low levels knowlesi. This can accurately classify recent infections while reducing misclassification infections.