High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor

Leptin [SDV]Life Sciences [q-bio] morbidity age-related changes mortality 3. Good health Obesity, Morbid consanguinity Cross-Sectional Studies leptin-signaling deficiency body growth Report oxidative stress Humans Morbidity Child metabolism monogenic obesity Retrospective Studies
DOI: 10.1016/j.xcrm.2023.101187 Publication Date: 2023-09-01T14:27:16Z
ABSTRACT
The long-term clinical outcomes of severe obesity due to leptin signaling deficiency are unknown. We carry out a retrospective cross-sectional investigation large cohort children with (LEP), LEP receptor (LEPR), or melanocortin 4 (MC4R) (n = 145) evaluate the progression disease. affected individuals undergo physical, clinical, and metabolic evaluations. report very high mortality in (26%) LEPR (9%), mainly pulmonary gastrointestinal infections. In addition, 40% surviving experience life-threatening episodes lung Although precision drugs currently available for deficiencies, as yet, they not accessible Pakistan. An appreciation impact on morbidity early mortality, educational attainment, attendant stigmatization should spur efforts deliver life-saving these matter urgency.
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