Bioinspired and biomimetic cancer-cell-derived membrane nanovesicles for preclinical tumor-targeted nanotheranostics

• DOI: 10.1016/j.xcrp.2023.101648
• Publication Date: 2023-10-18T14:57:02Z
• Authors: Rajendra Prasad; Bárbara B. Mendes; Mahadeo Gorain; Gopal Chandra Kundu; Narendra Gupta; Berney Peng; Eaint Honey Aung Win; He Qing; João Conde
• Keywords: Biocompatibility

Bioinspired cell-membrane-camouflaged nanohybrids have been proposed to enhance tumor targeting by harnessing their immune escape and self-recognition abilities. In this study, we introduce cancer-cell-derived membrane nanovesicles (CCMVs) integrated with gold nanorods (AuVNRs) in addition therapeutic imaging cargos such as doxorubicin indocyanine green. This approach enhances targeted enables synergistic chemo-phototherapeutics for solid tumors. CCMVs demonstrate significant penetration retention, serving nanotheranostics accessible surface biomarkers, biomimicking properties, homologous By evading uptake the mononuclear phagocytic system, can diffuse into deep core, leading precise reduction while preserving surrounding healthy tissues. Notably, intravenous administration of these theranostic agents ensures biocompatibility, evidenced a survival period approximately two months (up 63 days) without any observed side effects. Our findings underscore diagnostic potential biomimetic platform.