OpenPBTA: The Open Pediatric Brain Tumor Atlas

• DOI: 10.1016/j.xgen.2023.100340
• Publication Date: 2023-05-31T14:36:26Z
• Authors: Joshua A. Shapiro; Krutika S. Gaonkar; Stephanie J. Spie...; Candace L. Savonen; Chante J. Bethell; Run Jin; Komal S. Rathi; Yuankun Zhu; Laura E. Egolf; Bailey K. Farrow; Daniel P. Miller; Yang Yang; Tejaswi Koganti; Nighat Noureen; Mateusz P. Koptyra; Nhat Duong; Mariarita Santi; Jung Kim; Shannon Robins; Phillip B. Storm; Stephen C. Mack; Jena V. Lilly; Hongbo M. Xie; Payal Jain; Pichai Raman; Brian R. Rood; Rishi R. Lulla; Javad Nazarian; Adam A. Kraya; Zalman Vaksman; Allison P. Heath; Cassie Kline; Laura Scolaro; Angela N. Viaene; Xiaoyan Huang; Gregory P. Way; Steven M. Foltz; Bo Zhang; Anna R. Poetsch; Sabine Mueller; Brian M. Ennis; Michael Prados; Sharon J. Diskin; Siyuan Zheng; Yiran Guo; Shrivats Kannan; Angela J. Waanders; Ashley S. Margol; Meen Chul Kim; Derek Hanson; Nicholas Van Kuren; Jessica Wong; Rebecca S. Kaufman; Noel Coleman; Christopher Blackden; Kristina A. Cole; Jennifer L. Mason; Peter J. Madsen; Carl J. Koschmann; Douglas R. Stewart; Eric Wafula; Miguel A. Brown; Adam C. Resnick; Casey S. Greene; Jo Lynne Rokita; Jaclyn N. Taroni
• Keywords: Brain tumor

Pediatric brain and spinal cancers are collectively the leading disease-related cause of death in children; thus, we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, Children's Brain Tumor Network (CBTN) Pacific Neuro-Oncology Consortium (PNOC) created a systematic process tumor biobanking, model generation, sequencing with immediate access to harmonized data. We leverage data establish OpenPBTA, an open collaborative project over 40 scalable analysis modules that genomically characterize 1,074 pediatric Transcriptomic classification reveals universal