A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body

• DOI: 10.1016/j.xinn.2023.100380
• Publication Date: 2023-01-05T17:55:42Z
• Authors: Shuhui Sun; Shuai Ma; Yusheng Cai; Si Wang; Jie Ren; Yuanhan Yang; Jiale Ping; Xuebao Wang; Yiyuan Zhang; Haoteng Yan; Wei Li; Concepcion Rodrig...; Yan Yu; Feifei Liu; Juan Carlos Izpis...; Weiqi Zhang; Jing Qu; Guang-Hui Liu
• Keywords: Physical exercise; Exercise physiology

•An atlas of age-, tissue-, and cell-type-specific benefits long-term exercise.•Exercise protects tissues from infectious injury, especially in younger ones.•Exercise promotes rejuvenation aged tissues, the nervous system.•Exercise exerts geroprotective effects, by resetting circadian programs via clock protein BMAL1. Exercise whole organism, yet, how across body orchestrally respond to exercise remains enigmatic. Here, young old mice, with or without exercise, exposed we characterized phenotypic molecular adaptations a 12-month 14 tissues/organs at single-cell resolution. Overall, although more effectively animals, individuals terms inflammaging suppression tissue rejuvenation, structural improvement central system systemic vasculature being most prominent. In vascular endothelial cells, found that readjusting rhythmic machinery core BMAL1 delayed senescence facilitated recovery damage, recapitulating beneficial effects exercise. Our study underscores effect reconstituting youthful network provides foundation for further investigating interplay between aging, immune challenges organism.