Investigation of a chronic single-stage sheep Fontan model

• DOI: 10.1016/j.xjon.2024.06.018
• Publication Date: 2024-07-04T17:03:19Z
• Authors: John M. Kelly; Zinan Hu; Felipe Takaesu; Tatsuya Watanabe; Judd Storrs; Benjamin Blais; Satoshi Yuhara; Adrienne Morrison; Kirsten Nelson; Anudari Ulziibayar; Eric Heuer; Cole Anderson; Michael Jimenez; Joseph Leland; Raphael Malbrue; Carmen Arsuaga-Zo...; Laurie Goodchild; Aymen Naguib; Christopher McKee; Jordan Varner; Cameron DeShetler; Joshua Spiess; Andrew Harrison; Brian Boe; Aimee K. Armstrong; Arash Salavitabar; Kan Hor; Rajesh Krishnamurthy; Andrew R. Yates; Toshiharu Shinoka; Sergio A. Carrillo; Michael E. Davis; Alison L. Marsden; Christopher K. Br...

Our goal was to conduct a hemodynamic analysis of novel animal model Fontan physiology. Poor late-term outcomes in patients are believed arise from Fontan-induced hemodynamics, but the mechanisms remain poorly understood. Recent advances surgical experimentation have resulted development chronic sheep physiology; however, detailed this is lacking.