Chemoprophylactic Anticoagulation 72 Hours After Spinal Fracture Surgical Treatment Decreases Venous Thromboembolic Events Without Increasing Surgical Complications

• DOI: 10.1016/j.xnsj.2022.100141
• Publication Date: 2022-07-12T06:46:46Z
• Authors: Khaled Taghlabi; Brandon B． Carlson; Joshua Bunch; R． Sean Jackson; Robert Winfield; Douglas C． Burton
• Keywords: Chemoprophylaxis; Abbreviated Injury Scale; Bleed

Prophylactic anticoagulation is commonly used following operative treatment of spinal fractures to prevent Venous Thromboembolism (VTE) but carries a risk bleeding complications. The purpose the study was compare VTE and complications for MID (≤72h) versus LATE (>72h) chemoprophylaxis timing after fracture intervention.This retrospective review patients treated that received between May 2015 June 2019. Chemoprophylaxis initiation (MID vs. LATE) primary grouping variable. Patients with traumatic brain injury or evidence intracranial intraspinal bleed were excluded. Demographics, mechanisms, procedures, administration prophylaxis, Injury Severity Score (ISS) Spine Abbreviated Scale (AIS), including collected. Predictors identified using binary logistic regression.Eighty-eight (65M, 23F) met inclusion criteria. median age 55 years, 14. had 68 20. Nine developed (6 LATE, 3 MID, p<0.01). Three complications, all occurred in group (p=0.01). ISS (p<0.01) GCS also correlated an increased rate.Chemoprophylactic at 72 hours surgically demonstrates lower rate without increasing prophylaxis can be initiated spine fixation decrease postinjury morbidity mortality this high-risk patient population.