Impact of Tumor Pigmentation in 6934 Patients with Uveal Melanoma at a Single Center

• DOI: 10.1016/j.xops.2024.100585
• Publication Date: 2024-07-26T19:09:52Z
• Authors: Samuel J. Goldstein; Ferris Bayasi; George Thomas; Matthew Barke; Michael K. Nguyen; Samantha Pastore; Carol L. Shields
• Keywords: Single Center; Center (category theory)

PurposeTo evaluate clinical features and outcomes associated with degree of tumor pigmentation in patients uveal melanoma (UM) the choroid ciliary body.DesignRetrospective observational study.Subjects6,934 consecutive choroidal or body between 1971 2007 from a single ocular oncology center.MethodsData on patient demographics, characteristics, treatment approach, were collected. Comparisons pigmented (>80% by surface area), partially (20-80%), non-pigmented tumors (<20%) performed using relevant hypothesis testing. Survival analyses for metastasis melanoma-related death conducted Kaplan-Meier method log-rank tests univariate comparisons. A multivariate Cox regression analysis was to assess independent effects multiple covariates time-to-metastasis.Main Outcome MeasuresExtraocular extension, melanocytosis, time recurrence, location, death.ResultsThere 6,934 eyes UM classified as (n=3,762; 54%), (n=2,115; 31%) (n=1,057; 15%). Pigmented extraocular extension (p<0.001), melanocytosis (p=0.003), earlier recurrence more anterior epicenter location (ciliary body, equator ora serrata) (p<0.001). UMs also exhibited highest 10-year rate at 26%, compared 19% 16% survival curves demonstrated differences among groups (p<0.001) Multivariate showed that had 29% higher relative risk developing (p=0.002) 54% (p<0.001).ConclusionPigmented is often epicenter, recurrence. We revealed demonstrate metastatic disease have decreased UMs.