Bone marrow mesenchymal stem cell-derived exosomal miR-34c-5p ameliorates RIF by inhibiting the core fucosylation of multiple proteins

• DOI: 10.1016/j.ymthe.2021.10.012
• Publication Date: 2021-10-22T03:59:56Z
• Authors: Xuemei Hu; Nan Shen; Anqi Liu; Weidong Wang; Lihua Zhang; Zhigang Sui; Qingzhu Tang; Xiangning Du; Ning Yang; Wantao Ying; Biaojie Qin; Zhitong Li; Lin Li; Nan Wang; Hongli Lin
• Keywords: Fucosylation; Myofibroblast; Pericyte

Renal interstitial fibrosis (RIF) is an incurable pathological lesion in chronic kidney diseases. Pericyte activation the major characteristic of RIF. Fibroblast and macrophage are also involved Studies have revealed that core fucosylation (CF), important post-translational modification proteins, plays a key role pericyte RIF by regulating multiple profibrotic signaling pathways as hub-like target. Here, we reveal mesenchymal stem cell (MSC)-derived exosomes reside specifically injured deliver microRNA (miR)-34c-5p to reduce cellular inhibiting CF. Furthermore, showed CD81-epidermal growth factor receptor (EGFR) ligand-receptor complex aids entry exosomal miR-34c-5p into pericytes, fibroblasts, macrophages. Altogether, our findings novel MSC-derived multicellular via CF provide potential intervention strategy for renal fibrosis.