Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation

• DOI: 10.1016/j.ynstr.2022.100481
• Publication Date: 2022-09-03T03:36:24Z
• Authors: Sachin Patel; Keenan Johnson; Danielle Adank; Luis E. Rosas-Vidal
• Keywords: Infralimbic cortex

The prefrontal cortex is highly susceptible to the detrimental effects of stress and has been implicated in pathogenesis stress-related psychiatric disorders. It not well understood, however, how represented at neuronal level cortical ensembles. Even less understood representation changes over time with repeated exposure. Here we show that prelimbic ensemble foot shock exhibits rapid spatial drift within between sessions. Despite this ensemble, stressor itself stabilizes days. Our results suggest by rapidly drifting ensembles despite drift, important features are stabilized, suggesting a neural correlate habituation present neuron populations.