Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions*

• DOI: 10.1016/s0009-9236(97)90166-1
• Publication Date: 2005-02-01T12:33:49Z
• Authors: Eero A. Sotaniemi; Arno J. Arranto; Olavi Pelkonen; Markku Pasanen
• Keywords: Clearance rate

Objectives The effect of aging on drug metabolism in humans has not yet been completely described. Methods Two hundred twenty-six patients with equal histopathologic conditions were investigated. cytochrome P450 contents the liver biopsy samples, plasma antipyrine clearance rates after oral administration and, as an independent control vitality, serum testosterone levels determined. Results Cytochrome content subjects from 20 to 29 years age was 7.2 ± 2.6 nmol · gm−1, increased during fourth decade (+ 7.2%, p = NS), declined 40 (−16%, < 0.01) a level that remained unaltered up 69 years, and further 70 (−32%, 0.001). (phenazone) rate young 46.4 18.5 ml min−1, decade, by 0.34 min−1 per year toward old (−29%, half-life 9.5 2.0 hours 30 (+26%, volume distribution, 0.46 0.12 L kg−1 subjects, decreased (−11%). In line content, decrease both sexes. Conclusion This study shows reduction vitro vivo humans. data suggest at least three groups—young, middle-aged, elderly—should be included evaluation pharmacokinetics new drug. (−30%) indicates care is needed prescription drugs for elderly subjects. Clinical Pharmacology & Therapeutics (1997) 61, 331–339; doi: