Synthetic studies on ophiobolins

• DOI: 10.1016/s0040-4039(00)80638-3
• Publication Date: 2002-07-25T16:28:28Z
• Authors: Michael Rowley; Yoshito Kishi
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract The tricyclic ketone 14, an ophiobolin analogue lacking only the C-ring side chain, was synthesized in optically active form; the key step was the intramolecular NiCl2/CrCl2 mediated coupling of 10 to yield 11.