Myometrial and placental artery reactivity alone cannot explain reduced placental perfusion in pre-eclampsia and intrauterine growth restriction

• DOI: 10.1016/s1470-0328(03)02368-1
• Publication Date: 2003-10-11T05:52:40Z
• Authors: S Ong
• Keywords: Intrauterine growth restriction; Myograph

Objectives (1) To investigate a possible association between myometrial and placental artery vasoreactivity perfusion at the basal chorionic plates, respectively. (2) confirm that arteries from women with pre-eclampsia intrauterine growth restriction exhibit an attenuated endothelium-dependent vasodilatory response. Methods Women normal pregnancy, had magnetic resonance scan to assess using technique called intravoxel incoherent motion. At delivery, plate were assessed on wire myograph. Vessels pre-constricted thromboxane mimetic U46619 dilated incremental doses of bradykinin. Results Pre-constricted or exhibited response bradykinin, compared pregnancy (P < 0.0001). minimal in all three groups = 0.10). Maximal constrictor responses not associated perfusing fraction plate. Conclusion We Apart small arteries, other factors may be involved control perfusion.