Mortality in hospitalized SARS-CoV-2 patients with contemporaneous bacterial and fungal infections

• DOI: 10.1017/ash.2024.424
• Publication Date: 2024-09-23T10:07:54Z
• Authors: John J. Hanna; Zachary M. Most; Lauren N. Cooper; Abdi D. Wakene; Alexander P. Radu...; Christoph U. Lehmann; Trish M. Perl; Richard J. Medford
• Keywords: Original Article; Infectious and parasitic diseases; RC109-216; Public aspects of medicine; RA1-1270

Abstract Background: The interplay between SARS-CoV-2 and contemporaneous bacterial or fungal culture growth may have crucial implications for clinical outcomes of hospitalized patients. This study aimed to quantify the effect microbiological positivity on mortality among patients with SARS-CoV-2. Methods: In this retrospective cohort study, we included adult from OPTUM COVID-19 specific data set, who tested positive within 14 days hospitalization 01/20/2020 01/20/2022. We examined individuals organisms growing cultures bloodstream infections (BSIs), urinary tract, respiratory a composite three sites. used propensity score matching covariates demographics, comorbidities, parameters. sensitivity analysis, same but excluded critical care variables such as length stay, intensive unit stays, mechanical ventilation, extracorporeal membrane oxygenation. Results: 104,560 across United States. unadjusted odds increased significantly BSIs (98.7%) (RC) (176.6%), not (UC). Adjusted analyses showed that RC independently contribute mortality, even after accounting variables. Conclusions: SARS-CoV-2-positive patients, cultures, especially RC, are associated an risk disease severity. These findings underscore importance stringent infection control effective management secondary improve patient outcomes.