483 Human leukocyte antigen (HLA) alleles associated with severe COVID-19 outcomes in the All of Us cohort

• DOI: 10.1017/cts.2024.1074
• Publication Date: 2025-03-26T03:58:20Z
• Authors: Grace Kim; Grace J. Kim; Nayane Brito; San Chu; Ronald Horswell; Nicolas Vince; Lucio Miele

Objectives/Goals: The primary objective of this study is to investigate the relationship between human leukocyte antigen (HLA) alleles COVID-19 clinical severity, specifically: hospitalization, mortality, pneumonia by COVID-19, post-acute sequelae SARS-CoV-2 infection (PASC), and lab values. Methods/Study Population: We are conducting a retrospective cohort utilizing All Us controlled tier dataset. base population was defined as any patients with diagnosis code (ICD-10: U07.1 or SNOMED: 840539006) genomic sequencing data. PASC definitions were developed N3C consortium refined in house. A total 15,252 (64.5% female; 50.4% self-reported European ancestry; 18.8% African 34.5% > 65 years old) included study. HLA Class I II will be imputed from global diversity reference panel HIBAG “R” package. Results/Anticipated Results: Controlling for age, sex, race, vaccination status, we anticipate determining associated severe outcomes, such Pneumonia COVID (n = 1,436) (ICD-10:U09.9 SNOMED:119303003 OMOP:OMOP5160861 [n 498]). assess which markedly different IgM IgG serum antibody levels 1,024). Coexisting conditions, i.e., type 2 diabetes, chronic obstructive pulmonary disease, hypertension, Charlson comorbidity index. accuracy allelic imputation validated long-read whole genome sequences. Discussion/Significance Impact: Our findings can help identify who may at risk infection, particularly those undergoing bone marrow organ transplantation. hope accelerate personalized care vulnerable populations.