542 The association between cell-free DNA and lung transplant survival

• DOI: 10.1017/cts.2024.1114
• Publication Date: 2025-03-26T03:58:20Z
• Authors: Rohan Meda; Yi-Ping Fu; Hyesik Kong; Moon Kyoo Jang; Temesgen Andargie; Woojin Park; Jae Lee; Ilker Tunc; Gerald J Berry; Charles C Marboe; Pali D Shah; Steven D Nathan; Michael B Keller; Sean Agbor-Enoh
• Keywords: Association (psychology)

Objectives/Goals: Lung transplant is a life-saving surgery for patients with advanced lung diseases yet long-term survival remains poor. The clinical features and injury patterns of recipients who die early versus those survive longer term remain undefined. Here, we use cell-free DNA rejection parameters to help elucidate this further. Methods/Study Population: candidacy prioritizes have high mortality risk within 2 years will likely beyond 5 years. We stratified died as death (n = 50) survived past survivors 53). had serial blood collected part two prospective cohort studies. Cell-free (cfDNA) was quantified using relative (% donor-derived cfDNA {%ddcfDNA}) absolute (nuclear-derived {n-cfDNA}, mitochondrial-derived {mt-cfDNA}) measurements. As routine posttransplant care, all underwent pulmonary function testing (PFT), surveillance bronchoscopy bronchoalveolar lavage (BAL), transbronchial biopsy (TBBx), donor-specific antibody (DSA). Results/Anticipated Results: Over the first after transplant, number episodes antibody-mediated (p) Discussion/Significance Impact: Clinically, early-death perform worse on PFTs experience degree CLAD. These also higher levels by n-cfDNA mt-cfDNA. results provide preliminary evidence that allograft rejection, dysfunction, molecular injury.