What is the true nature of the relationship between metabolic disturbance, specifically of glucose and insulin metabolism, and depressive and other mood disorders?

• DOI: 10.1017/dep.2023.15
• Publication Date: 2023-10-11T09:31:16Z
• Authors: Elizabeth M. Scott; Ian B. Hickie; Jacob J. Crouse; Mirim Shin
• Keywords: Carbohydrate Metabolism

Much attention in recent years has focused on the extent to which risk of metabolic disturbances, and most fundamentally glucose insulin, are prevalent among those treated for depressive other mood disorders (Osimo et al., 2021; Scott 2019; Tickell 2022). Public concern also increased rates premature mortality with chronic depression major mental disorders, a significant proportion that being due early-onset cardiovascular disease (particularly women). A common assumption is much this consequence medical treatments depression, their possible adverse effects such as diabetes, presumably mediated by long-term weight gain.