Characteristics, costs, and outcomes associated with central-line–associated bloodstream infection and hospital-onset bacteremia and fungemia in US hospitals

• DOI: 10.1017/ice.2023.132
• Publication Date: 2023-07-10T06:31:43Z
• Authors: Kalvin C. Yu; Molly Jung; ChinEn Ai
• Keywords: Fungemia; Bacteremia; Bloodstream infection; Central line

Abstract Objectives: To compare characteristics and outcomes associated with central-line–associated bloodstream infections (CLABSIs) electronic health record–determined hospital-onset bacteremia fungemia (HOB) cases in hospitalized US adults. Methods: We conducted a retrospective observational study of patients 41 acute-care hospitals. CLABSI were defined as those reported to the National Healthcare Safety Network (NHSN). HOB was positive blood culture an eligible organism collected during period (ie, on or after day 4). evaluated patient characteristics, other cultures (urine, respiratory, skin soft-tissue), microorganisms cross-sectional analysis cohort. explored adjusted [length stay (LOS), hospital cost, mortality] 1:5 case-matched Results: The included 403 NHSN-reportable CLABSIs 1,574 non-CLABSI HOB. A non-bloodstream same microorganism 9.2% 32.0% patients, most commonly urine respiratory cultures. Coagulase-negative staphylococci Enterobacteriaceae common cases, respectively. In analyses, HOB, separately combined, significantly longer LOS [difference, 12.1–17.4 days depending intensive care unit (ICU) status], higher costs (by $25,207–$55,001 per admission), >3.5-fold increased risk mortality ICU encounter. Conclusions: are significant increases morbidity, mortality, cost. Our data may help inform prevention management infections.