Molecular characterization of a suspected IMP-type carbapenemase-producing Pseudomonas aeruginosa outbreak reveals two simultaneous outbreaks in a tertiary-care hospital

• DOI: 10.1017/ice.2023.75
• Publication Date: 2023-05-04T03:15:40Z
• Authors: Ana Gual-de-Torrella; Carla López-Causape; Izaskun Alejo-Cancho; Estrella Rojo-Mol...; Gonzalo Sanchez-G...; Sara Cortés-Lara; María B. Rodrígue...; Pilar Berdonces-G...; María J. Lopez de...; Antonio Oliver
• Keywords: clone (Java method); Molecular Epidemiology; Multilocus sequence typing

To describe IMP-type carbapenemase-producing Pseudomonas aeruginosa outbreaks at Galdakao University Hospital between March 2021 to December 2021.Outbreak report.Galdakao is a tertiary-care hospital in the Basque Country (northern Spain).All patients with positive carbapenemase producing (IMP-PA) culture were included this study, both colonization and infection cases.An outbreak investigation was conducted, which molecular epidemiology analysis [pulsed-field gel electrophoresis whole-genome sequencing (WGS)] environmental screenings performed.Between 2021, 21 cases of IMP-PA detected Hospital: 18 3 cases. In total, 4 different pulsotypes belonging clones according WGS: ST175 (n = 14), ST633 3), ST179 ST348 1). IMP-13 most isolates clone all clones, whereas IMP-29 clone. Clinical isolated mainly from admitted respiratory ward, ICU. Two ward.Molecular genomic revealed that there had been 2 independent outbreaks, one long duration ward other more limited