Risk factors for long coronavirus disease 2019 (long COVID) among healthcare personnel, Brazil, 2020–2022

• DOI: 10.1017/ice.2023.95
• Publication Date: 2023-06-05T10:16:50Z
• Authors: Alexandre R. Marra; Vanderson Souza S...; Mina Cintho Ozahata; Rafael Lopes; Anderson F. Brito; Marcelo Bragatte; Jorge Kalil; João Luiz Miraglia; Daniel Tavares Ma...; Yang Guozhang; Vanessa Damazio T...; Elivane da Silva ...; João Renato Rebel...; Adriana Cypriano; Laura Wanderly Vi...; Miria Polonio; Solange Miranda d...; Victória Catharin...; Aline Miho Maezato; Gustavo Yano Callado; Guilherme de Paul...; Ketti Gleyzer de ...; Rúbia Anita Ferra...; Fernanda de Mello...; Deyvid Amgarten; Ana Laura Boechat; Takaaki Kobayashi; Eli Perencevich; Michael B. Edmond; Luiz Vicente Rizzo
• Keywords: Coronavirus; 2019-20 coronavirus outbreak; Disease Control

Abstract Objective: To determine risk factors for the development of long coronavirus disease 2019 (COVID-19) in healthcare personnel (HCP). Methods: We conducted a case–control study among HCP who had confirmed symptomatic COVID-19 working Brazilian system between March 1, 2020, and July 15, 2022. Cases were defined as those having COVID according to Centers Disease Control Prevention definition. Controls documented but did not develop COVID. Multiple logistic regression was used assess association exposure variables during 180 days follow-up. Results: Of 7,051 diagnosed with COVID-19, 1,933 (27.4%) developed compared 5,118 (72.6%) not. The majority (51.8%) 3 or more symptoms. Factors associated female sex (OR, 1.21; 95% CI, 1.05–1.39), age 1.01; 1.00–1.02), 2 SARS-CoV-2 infections 1.27; 1.07–1.50). Those infected δ (delta) variant 0.30; 0.17–0.50) o (omicron) 0.49; 0.30–0.78), receiving 4 vaccine doses prior infection 0.05; 0.01–0.19) significantly less likely Conclusions: Long can be prevalent HCP. Acquiring >1 major factor COVID, while maintenance immunity via vaccination highly protective.