Vitamin D and inflammatory markers: cross-sectional analyses using data from the English Longitudinal Study of Ageing (ELSA)

• DOI: 10.1017/jns.2016.37
• Publication Date: 2017-01-12T03:08:33Z
• Authors: Cesar de Oliveira; Jane P. Biddulph; Vasant Hirani; Ione Jayce Ceola ...
• Keywords: Longitudinal Study; White blood cell; Cross-sectional study

Recent evidence suggests that low vitamin D concentrations are associated with increased levels of inflammatory markers. However, there limited studies investigating associations between and markers in the general population much this older adults is inconclusive. Therefore, study investigates cross-sectional association serum 25-hydroxyvitamin (25(OH)D) 5870 English from wave 6 (2012-2013) Longitudinal Study Ageing (ELSA). ELSA a large prospective observational community-dwelling people aged 50 years over England. Serum 25(OH)D levels, C-reactive protein (CRP) plasma fibrinogen white blood cell count (WBC), age, season collection, waist circumference, total non-pension household wealth, measures health behaviours included depression, number cardiovascular, non-cardiovascular conditions difficulties activities daily living, smoking, physical activity were measured. There was significant negative (≤30 nmol/l) CRP (OR 1·23, 95 % CI 1·00, 1·51) WBC 1·35, 1·13, 1·60) remained after adjustment for wide range covariates clinical significance. fibrinogen, did not remain when circumference entered final model. Our findings showed two out three investigated. The independent inverse inflammation potential anti-inflammatory role individuals population.