A prospective study of intake oftrans-fatty acids from ruminant fat, partially hydrogenated vegetable oils, and marine oils and mortality from CVD

• DOI: 10.1017/s0007114511005897
• Publication Date: 2011-11-08T11:44:42Z
• Authors: Ida Laake; Jan I. Pedersen; Randi Selmer; Bente Kirkhus; Anja S. Lindman; Aage Tverdal; Marit B. Veierød
• Keywords: Adult; Male; Meat; Food Handling; Cohort Studies; 03 medical and health sciences; Fish Oils; 0302 clinical medicine; Risk Factors; Animals; Humans; Mass Screening; Plant Oils; Prospective Studies; 2. Zero hunger; Sex Characteristics; Norway; Ruminants; Middle Aged; 3. Good health; Cardiovascular Diseases; Female; Dairy Products; Follow-Up Studies

Trans -fatty acids (TFA) have adverse effects on blood lipids, but whether TFA from different sources are associated with risk of CVD remains unresolved. The objective the present study was to evaluate association between intake partially hydrogenated vegetable oils (PHVO), fish (PHFO) and ruminant fat (rTFA) risks death CVD, CHD, cerebrovascular diseases sudden in Norwegian Counties Study, a population-based cohort study. Between 1974 1988, participants were examined for up three times. Fat assessed semi-quantitative FFQ. A total 71 464 men women followed through 2007. Hazard ratios (HR) 95 % CI estimated Cox regression. Energy compared energy all other sources, carbohydrates or unsaturated cis multivariable models. During follow-up, 3870 subjects died 2383 732 243 death. Significant risks, comparing highest lowest category, found for: PHVO CHD (HR 1·23 (95 1·00, 1·50)) 0·65 0·45, 0·94)); PHFO 1·14 1·03, 1·26)) 1·32 1·04, 1·69)); rTFA 1·30 1·05, 1·61)), 1·50 1·11, 2·03)) 2·73 1·19, 6·25)) women. These associations not significant ( P interaction ≥ 0·01). supports that intake, irrespective source, increases risk. Whether decreases warrants further investigation.