Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health

• DOI: 10.1017/s0007114513001505
• Publication Date: 2013-08-01T10:13:56Z
• Authors: Ruud Albers; Raphaëlle Bourdet...; Deborah Braun; Philip C. Calder; Udo Herz; Claude Lambert; Irene Lenoir-Wijn...; Agnès Méheust; Arthur Ouwehand; Phoukham Phothirath; Tomoyuki Sako; Seppo Salminen; André Siemensma; Henk van Loveren; Ulrich Sack
• Keywords: Relevance

Optimal functioning of the immune system is crucial to human health, and nutrition one major exogenous factors modulating different aspects function. Currently, no single marker available predict effect a dietary intervention on To provide further guidance assessment interpretation modulation functions due in general population, International Life Sciences Institute Europe commissioned group experts from academia, government food industry prepare document. A draft this paper was refined at workshop involving additional experts. First, expert defined criteria evaluate usefulness function markers. Over seventy-five markers were scored within context three distinct functions: defence against pathogens; avoidance or mitigation allergy; control low-grade (metabolic) inflammation. The most useful subsequently classified depending whether they by themselves signify clinical relevance and/or involvement Next, five theoretical scenarios drafted describing potential changes values compared with relevant reference range. Finally, all elements combined, providing framework aid design studies assessing effects This stepwise approach offers clear rationale for selecting future trials provides outcomes. similar may also be rationalise selection other physiological processes critical maintenance health well-being.