Effect of sardine proteins on hyperglycaemia, hyperlipidaemia and lecithin:cholesterol acyltransferase activity, in high-fat diet-induced type 2 diabetic rats

• DOI: 10.1017/s0007114515004195
• Publication Date: 2015-10-28T03:39:03Z
• Authors: Nora Benaicheta; Fatima Z. Labbaci; Malika Bouchenak; Farida O. Boukortt
• Keywords: Sterol O-acyltransferase; Reverse cholesterol transport

Abstract Type 2 diabetes (T2D) is a major risk factor of CVD. The effects purified sardine proteins (SP) were examined on glycaemia, insulin sensitivity and reverse cholesterol transport in T2D rats. Rats fed high-fat diet (HFD) for 5 weeks, injected with low dose streptozotocin, used. diabetic rats divided into four groups, they casein (CAS) or SP combined 30 % lipids, 4 weeks. HFD-induced hyperglycaemia, resistance hyperlipidaemia HFD, regardless the consumed protein. In contrast, these parameters lowered serum values reduced v. CAS. HFD significantly increased total TAG concentrations liver serum, whereas decreased SP, lipid intake. Faecal excretion was higher v . CAS, lipids. Lecithin:cholesterol acyltransferase (LCAT) activity HDL 3 -phospholipids (PL) CAS-HF than -cholesteryl esters (CE) lower. Otherwise, LCAT -CE group CAS group, -PL -unesterified Moreover, SP-HF when higher. conclusion, results indicate potential to improve transport,