Barleyβ-glucan reduces blood cholesterol levels via interrupting bile acid metabolism

• DOI: 10.1017/s0007114517002835
• Publication Date: 2017-11-08T10:05:15Z
• Authors: Yanan Wang; Scott V. Harding; Sijo J. Thandapilly; Susan M. Tosh; Peter J. H. Jones; Nancy P. Ames
• Keywords: Dietary Fiber; Male; 2. Zero hunger; 0301 basic medicine; Carbon Isotopes; 0303 health sciences; Cross-Over Studies; Genotype; Plant Extracts; Hypercholesterolemia; Hordeum; Cholesterol, LDL; Middle Aged; Bile Acids and Salts; Cholesterol, Dietary; Molecular Weight; 03 medical and health sciences; Cholesterol; Intestinal Absorption; Humans; Female; Cholesterol 7-alpha-Hydroxylase; Alleles; Cholestenones

Abstract Underlying mechanisms responsible for the cholesterol-lowering effect of β -glucan have been proposed, yet not fully demonstrated. The primary aim this study was to determine whether consumption barley lowers cholesterol by affecting absorption, synthesis or bile acid synthesis. In addition, aimed assess underlying are related 7 α hydroxylase ( CYP7A1 ) SNP rs3808607 as proposed us earlier. a controlled, randomised, cross-over study, participants with mild hypercholesterolaemia n 30) were randomly assigned receive breakfast containing 3 g high-molecular weight (HMW), 5 low-molecular (LMW), LMW control diet, each weeks. Cholesterol absorption determined assessing enrichment circulating 13 C-cholesterol over 96 h following oral administration; fractional rate assessed measuring incorporation 2 H derived from deuterium oxide within body water pool into erythrocyte 24 h; serum -hydroxy-4-cholesten-3-one concentrations. Consumption HMW decreased total (TC) levels P =0·029), but did affect =0·25) =0·14). Increased after observed in all =0·049), and more pronounced individuals carrying homozygous G =0·033). linear relationship between log (viscosity) α- HC concentration allele carriers. Results indicate that increased rather than inhibition may be -glucan. TC reduction carriers previous due enhanced response high-viscosity those individuals.