Early detection of psychosis: positive effects on 5-year outcome

• DOI: 10.1017/s0033291710002023
• Publication Date: 2010-10-14T05:58:35Z
• Authors: T. K. Larsen; I. Melle; B. Auestad; U. Haahr; I. Joa; J. O. Johannessen; S. Opjordsmoen; B. R. Rund; J. I. Rossberg; E. Simonsen; P. Vaglum; S. Friis; T. McGlashan
• Keywords: Adult; Male; Psychiatric Status Rating Scales; Adolescent; Norway; Denmark; 05 social sciences; Middle Aged; Early intervention; 3. Good health; Young Adult; Early Diagnosis; Psychotic Disorders; Outcome Assessment, Health Care; outcome; Humans; Female; 0501 psychology and cognitive sciences; first-episode psychosis; Aged; Follow-Up Studies

Background During the last decades we have seen a new focus on early treatment of psychosis. Several reviews shown that duration untreated psychosis (DUP) is correlated to better outcome. However, it still unknown whether will lead long-term This study reports effects reducing DUP 5-year course and Method 1997–2000 total 281 consecutive patients aged >17 years with first episode non-affective were recruited, which 192 participated in follow-up. A comprehensive detection (ED) programme public information campaigns low-threshold teams was established one healthcare area (ED-area), but not comparable (no-ED area). Both areas ran equivalent programmes during 2 need-adapted thereafter. Results At start treatment, ED-patients had shorter less symptoms than no-ED-patients. There no significant differences (psychotherapy medication) for 5 years. Mixed-effects modelling showed scores ED group Positive Negative Syndrome Scale negative, depressive cognitive factors global assessment functioning social at The also more contacts friends. Regression analysis did find these could be explained by confounders. Conclusions Early positive clinical functional status follow-up