Somatodendritic 5-hydroxytryptamine1A(5-HT1A) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone

• DOI: 10.1017/s0033291713001475
• Publication Date: 2013-07-01T08:06:54Z
• Authors: R. H. McAllister-...; H. A. Alhaj; A. Massey; J. Pankiv; U. Reckermann
• Keywords: Autoreceptor; Depression

Background Positron emission tomography and post-mortem studies of the number somatodendritic 5-hydroxytryptamine 1A (5-HT ) autoreceptors in raphé nuclei have found both increases decreases depression. However, recent genetic suggest they may be increased and/or function. The current study examined effect buspirone on electroencephalographic (EEG) centroid frequency, a putative index 5-HT receptor functional status, cohort medication-free depressed patients controls. Method A total 15 (nine male) intelligence quotient (IQ)-, gender- age-matched healthy controls had resting EEG recorded from 29 scalp electrodes prior to 30, 60 90 min after oral (30 mg) administration. receptors was assessed by calculating frequency between 6 10.5 Hz. postsynaptic measuring plasma growth hormone, prolactin cortisol concentrations. Results Analysis variance revealed significantly greater compared with (F1,28 = 6.55, p 0.016). There no significant difference neuroendocrine responses two groups. Conclusions These findings are consistent an increase status somatodendritic, but not postsynaptic, autoreceptors, line hypotheses based data. This would hypothesized lead serotonergic negative feedback, hence decreased release at projection sites, patients.