Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study

• DOI: 10.1017/s003329171900196x
• Publication Date: 2019-08-15T14:18:37Z
• Authors: Jim van Os; Lotta-Katrin Pries; Philippe Delespaul; Gunter Kenis; Jurjen J. Luykx; Bochao D. Lin; Alexander L. Rich...; Berna Akdede; Tolga Binbay; Vesile Altınyazar; Berna Yalınçetin; Güvem Gümüş-Akay; Burçin Cihan; Haldun Soygür; Halis Ulaş; Eylem Şahin Canku...; Semra Ulusoy Kaymak; Marina M. Mihaljevic; Sanja Andric Petr...; Tijana Mirjanic; Miguel Bernardo; Bibiana Cabrera; Julio Bobes; Pilar A. Saiz; María Paz García-...; Julio Sanjuan; Eduardo J. Aguilar; José Luis Santos; Estela Jiménez-López; Manuel Arrojo; Angel Carracedo; Gonzalo López; Javier González-P...; Mara Parellada; Nadja P. Maric; Cem Atbaşoğlu; Alp Ucok; Köksal Alptekin; Meram Can Saka; ; Celso Arango; Michael O'Donovan; Bart P. F. Rutten; Sinan Guloksuz
• Keywords: Polygenic risk score; Expression (computer science)

First-degree relatives of patients with psychotic disorder have higher levels polygenic risk (PRS) for schizophrenia and intermediate phenotypes.We conducted, using two different samples discovery (n = 336 controls 649 siblings disorder) replication 1208 1106 siblings), an analysis association between PRS on the one hand psychopathological cognitive phenotypes other in a sample at average genetic (healthy controls) than patients). Two subthreshold psychosis phenotypes, as well standardised measure ability, based short version WAIS-III form, were used. In addition, jumping to conclusion bias (replication only) was tested PRS.In both sample, evidence observed patients, whereas no observed. Jumping similarly only associated sibling group. Cognitive ability weakly negatively non-significantly control group.The degree endophenotypic expression depends having disorder, suggestive underlying gene-environment interaction. biases may better index traditional measures neurocognition, which instead reflect population distribution impacting prognosis disorder.