Abnormal dynamic functional connectivity of hippocampal subregions associated with working memory impairment in melancholic depression

• DOI: 10.1017/s0033291721004906
• Publication Date: 2021-12-06T13:59:11Z
• Authors: Lai Shunkai; Ting Su; Shuming Zhong; Guangmao Chen; Yiliang Zhang; Hui Zhao; Pan Chen; Guixian Tang; Zhangzhang Qi; Jiali He; Yunxia Zhu; Sihui Lv; Zijin Song; Haofei Miao; Yilei Hu; Yanbin Jia; Ying Wang
• Keywords: Association (psychology)

Abstract Background Previous studies have demonstrated structural and functional changes of the hippocampus in patients with major depressive disorder (MDD). However, no analyzed dynamic connectivity (dFC) hippocampal subregions melancholic MDD. We aimed to reveal patterns for dFC variability – including bilateral rostral caudal areas its associations cognitive impairment Methods Forty-two treatment-naive MDD features 55 demographically matched healthy controls were included. The sliding-window analysis was used evaluate whole-brain each seed. assessed between-group differences values subregion whole brain performance on MATRICS Consensus Cognitive Battery (MCCB). Finally, association conducted investigate their relationships. Results Patients showed decreased between left anterior lobe cerebellum compared (voxel p < 0.005, cluster 0.0125, GRF corrected), poorer scores working memory, verbal learning, visual social cognition (all 0.05). Association that memory positively correlated hippocampus-left ( r = 0.338, 0.029) Conclusions These findings confirmed distinct pathway MDD, suggested dysfunction hippocampus-cerebellum may be underlying neural substrate